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Chunk #12 — Online methods — Final phasing and haplotype estimation

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A reference panel of 64,976 haplotypes for genotype imputation.
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We estimated haplotypes from GLPhase genotype calls using SHAPEIT312. Chromosomes were phased in chunks consisting of 16,000 variants plus 3,300 variants overlapping with neighboring chunks on either side. The non-default command line option -w 0.5 was used for SHAPEIT3. Chunks were ligated using the ligateHAPLOTYPES program (see URLs). SHAPEIT3 does not handle multiple variants at the same genomic coordinate, so multiallelic sites (SNPs with 3 or 4 alleles) were shifted by one or two base pairs for rephasing, and then moved back to their original position after chunk ligation.