variants show modest linkage disequilibrium to our WC associated SNP in UK samples (IVS1774_G/T and rs987237, r2 = 0.42; intron_1+2093_(A/C) and rs987237, r2 = 0.67). Thus, we see some evidence that the variants identified have anticipated effects on downstream phenotypes, although, as recently demonstrated for FTO (which has more marked effects on adiposity than the signals described here), analyses of this type have only limited power even in extremely large data sets [31].
