targets (Chen et al. 2009; Jones et al. 2006a; Jones et al. 2004). In this study, we also found several SNPs in both CHRM2 and GRM8 genes were significantly associated with frontal theta EROs; however, not quite at the level of genome-wide significance (Table S2). Another study endorsing a role for the thalamus in cognitively relevant brain rhythms has suggested both metabotropic glutamate receptor and muscarinic cholinergic receptor activation can cause rhythmic bursting at alpha/theta frequencies (Hughes et al. 2008). Since the GIRK2 is an important functional element in dopaminergic, cholinergic, GABAergic and glutamatergic synapses (Saenz del Burgo et al. 2008), a functional involvement of the GIRK2 channels in the oscillatory dynamics of theta band can be speculated.
