We assayed DNA and RNA from 134 post-mortem brains from individuals of European descent free of known neurological disorders. In all samples control status was confirmed by the lack of any significant pathology as judged by a senior neuropathologist. Exon-specific RNA expression was quantified using Affymetrix Human Exon 1.0 ST arrays in 10 brain regions: cerebellar cortex, frontal cortex, hippocampus, inferior olivary nucleus (sub-dissected from the medulla), occipital cortex, putamen (at the level of the anterior commissure), substantia nigra, temporal cortex, thalamus (at the level of the lateral geniculate nucleus) and intralobular white matter. DNA was genotyped using Illumina Omni1-quad and Immunochip arrays followed by imputation using the 1000 Genomes Project (March 2012 release) as reference. The quality control of the RNA preparation from this brain series and the reliability of the quantification of expression have been previously documented24. Further details on the data set generation, quality control and analysis are provided in the Online Methods and by Supplementary Table 1 and Supplementary Figure 1.
