far less prevalent in European populations (under 4%, Hurley and Edenberg, 2012), large-scale studies have demonstrated that A-allele carriers of European descent also exhibit lower levels of heavy and problem drinking (Bierut et al., 2012, Gelernter et al., 2014, Tolstrup et al., 2008). The rs1229984 has not been implicated as a source of genetic variance in AUD in individuals of African descent, but an association between alcohol dependence and another SNP on ADH1B, rs2066702, was observed in the AA subsample in our recent genomewide association study (GWAS) (Gelernter et al., 2014).
