To test whether variation in NR3C1 moderated the effects of the Fast Track intervention, we fitted a series of 10 linear probability models (one for each SNP) predicting the outcome of Any Externalizing Psychopathology at age 25 as a function of Fast Track treatment condition, SNP genotype, and a product term measuring the interaction between treatment and genotype: prob(Any Externalizing Psychopathology)=α+βTreatment+γGenotype+δTreatment×Genotype+νX+ε) where X is a vector of covariates. All models included sex as a covariate. Sensitivity analyses also included site, cohort, and pre-intervention severity-of-risk as covariates.
