While our study presents preliminary data with suggestive (P-values <0.05 and Q-values <0.06) evidence for eight of the eighteen SNPs tested for association with nicotine withdrawal sensitivity score, replication of our results in an independent sample is essential (64). These findings may stimulate future research on the role of variation, linkage disequilibrium, and population differences in genetic architecture at OPRM1 on nicotine withdrawal sensitivity score.
