The drug–gene interaction database (DGIdb, www.dgidb.org) was first released in 2013 to consolidate drug–gene interactions and potentially druggable genes into a single resource with a powerful interface to query these data (1). DGIdb 2.0 was released in 2016 and featured substantial content updates, a more intuitive user interface and the inclusion of an application programming interface (API) (2). Despite the success of the DGIdb, 2.0 became outdated in several ways. New sources have become available since 2.0’s release and many existing sources within the database required updates. The notion of grouping drug claims (an assertion of a drug concept by a constituent resource) to match a canonical drug source (PubChem compounds), and grouping gene claims (an assertion of a gene concept by a constituent resource) to a canonical gene source (NCBI Entrez Gene) was described in the 2.0 paper (3,4). In brief, grouping allows the DGIdb to relate disparate representations of a gene or drug concept through a core entity, or group. As the database grew, the grouping success rates dropped and new classes of drugs were not fully represented
