Despite the number of studies that examine whether adverse experiences or religiosity moderate genetic influences on other substance use behavior (i.e., alcohol33, nicotine13), no published GxE studies examine moderation of genetic influences on CUD employing PRS derived from large, recent genetic studies of cannabis behavior. In this study, we use results from the Pasman et al. meta-analysis of cannabis use to examine (1) whether genetic propensity to cannabis use extends to cannabis problems as measured by the DSM-5, and (2) whether two well-established psychosocial factors known to influence substance use behavior, frequency of religious service attendance and trauma exposure, moderate polygenic influences on cannabis use and DSM-5 CUD symptoms in an independent sample enriched with individuals at high risk for substance use disorders.
