Up to 60% of disorder risk genes were H-MAGMA selective (genes identified by H-MAGMA but not by cMAGMA), suggesting that functional genomics guided gene annotation can help identify novel genes and pathways (Extended Data Fig. 1b). H-MAGMA selective genes were significantly enriched for heritability in all nine brain disorders, demonstrating the increase in power of H-MAGMA (Fig. 1c, Extended Data Fig. 1e, Methods).
