We identified one novel additional locus with P < 5×10− at 14q32; the top SNP at this locus was rs754388 (nearest gene – RIN3), with a P-value of 5•25×10−9. We genotyped this SNP in the ICGN Study, and tested for association with COPD in ICGN using a family-based test. While the evidence of association at this SNP did not achieve statistical significance (one-sided P=0•20), the overall meta-analysis P-value (including ICGN) for rs754388 remained genome-wide significant (5•4×10−9). An analysis of the effect of this SNP on FEV1 as a quantative trait was not statistically significant.
