Significant group differences were found in eight white matter regions, including frontal association fibers such as frontal-occipital and superior longitudinal fasciculi. Bingers and binge+marijuana users displayed lower FA than controls (ps ≤ .016). Interestingly, bingers demonstrated significantly lower FA than the binge+marijuana group (ps .014 to .043). No significant MD differences were found in the 8 clusters identified by the FA analyses. Our findings suggest poorer white matter integrity in adolescents with histories of binge drinking than non-drinkers. However, teens with concomitant binge drinking and marijuana use showed a lesser degree of reduced fiber tract coherence than those engaging in binge drinking alone.
