Chunk #1 — Introduction

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

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PPP3CA/calcineruin acts as a calcium-activated heteromeric complex that contains calcium, calmodulin, a catalytic subunit and a regulatory subunit (Klee, Crouch, & Krinks, 1979). Other PPP3CA gene family members include the additional catalytic subunits, PPP3CB and PPP3CC and the regulatory subunits, PPP3R1 and PPP3R2.