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Chunk #14 — METHODS AND MATERIALS — CNV Burden Analysis

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Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.
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To ensure comparable CNV detection from different array types, CNV predictions from the shared set of probes common to all array platforms (n=213,819) was used for all case-control comparisons. For the overall burden analysis, we compared the proportion of subjects in each group harboring at least one predicted rare CNV.