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Chunk #16 — Results — Larger GWAS identifies new biologically relevant genes and pathways

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Defining the role of common variation in the genomic and biological architecture of adult human height.
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The DEPICT analysis also prioritized tissues and individual genes. We found that genes within associated height loci were enriched for expression in tissues related to chondrocytes (cartilage, joint capsule, synovial membrane, and joints; P<5.5×10−9, FDR<0.001), and other musculoskeletal, cardiovascular, and endocrine tissue-types (FDR<0.05) (Fig. 3; Supplementary Fig. 8; Supplementary Table 15). We also showed that a subset of the 697 height associated SNPs that represented lead cis-eQTLs in blood defined 75 genes that were collectively enriched for expression in cartilage (P=0.008) (Supplementary Note and Supplementary Table 8).