examining Negative Affect Alcoholism as a unique phenotype. Specifically, they report a higher rate of comorbid depression and alcoholism among probands of families with a higher prevalence of this same comorbidity as opposed to families with a higher prevalence of alcoholism alone. This finding spurred genetic analyses identifying two markers on chromosome 1 that indicate linkage between alcohol and depression (spectrum) disorders. Together, these findings indicate the potential for some overlap in the genetic diathesis for alcoholism and internalizing disorders. Thus, some COAs may have greater genetic vulnerability for internalizing disorders that is shared with that for alcoholism and this comorbidity may be greatest in children whose parents demonstrate Negative Affect Alcoholism.
