Due to the previously described relationship between CYP2E1 and the metabolism of ethanol and positive linkage results concerning the level of response to alcohol in relation to alcoholism, a number of single nucleotide polymorphisms (SNP) were genotyped in the CYP2E1 to further elucidate the gene’s role in alcohol response. Both genotype and copy number were tested for association with the level of response to alcohol as measured by the SHAS questionnaire. Combined linkage and association analysis was performed to determine whether a single marker or haplotype could account for the linkage signal seen at 10qter.
