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Chunk #144 — 6. Challenges facing genetic psychophysiology — 6.2. Methodological issues — 6.2.3. Issues related to genetic analysis

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Genetic psychophysiology: advances, problems, and future directions.
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Another important factor leading to increased rate of false-positive findings is multiple testing combined with selective reporting of only those statistical comparisons that yielded positive findings, for example, multiple measures can be derived from an ERP experiment and tested for association with multiple genetic polymorphisms, but only one test that yielded a significant finding may be described in the published report. Recent analyses of published studies support the notion that many more tests have been conducted than reported in the literature (Duncan and Keller, 2011; Flint and Munafo, 2012).