Here we present an association study of nicotine dependence across the CHRNA5-CHRNA3-CHRNB4 region in a new African-American (AA) sample and an expanded European-American (EA) sample. We also analyze novel variants discovered from DNA resequencing of EAs in a 26 kb region between CHRNA5 and CHRNA3. Our goal is to determine whether any variants consistently affect nicotine dependence risk in both EAs and AAs. Additionally, we are interested in evidence of variants that affect risk in the AA sample alone.
