to define strong BGS (P = 7.73 × 10−11). We also note that the τc statistic of the LDSC model was significant for BGS, in both the binary (P = 0.041) and quantitative (P = 0.023) analyses (Supplementary Table 8). The τc statistic indicates the enrichment of BGS after controlling for all other annotations in the model (including LoF-intolerant genes)26 and thus represents a robust and conservative test for BGS enrichment.
