60x coverage. By contrast, JointSNVMix HC and SomaticSniper HC have a sensitivity of ≤ 2.0%, and the sensitivity does not increase appreciably with tumor sequencing depth. Strelka HC detects just 4.6% of the events at 30x and only increases to 20.8% at 60x. Sensitivity for such low allelic fraction events is critical for characterizing impure tumors or subclonal mutations in heterogeneous tumors, and it appears that MuTect is much more sensitive in this regime.
