Third, the encoded protein of RGS17 is a member of the regulator of G-protein signaling family. The gene product of DCAF12, DDB1, and CUL4 associated factor 12 interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The locus 6q25.2 containing RGS17 was previously reported to be associated with major depressive and bipolar disorders (Ferreira et al. 2008; Liu et al. 2011), general cognitive ability (Davis et al. 2010), and tonometry (Levy et al. 2007).
