GxE studies focusing on other candidate genes, however, have found more consistent results. For example, studies examining FKBP5 and CHRH1 have shown that variants in these genes moderate the effect of exposure to child maltreatment, childhood adversities, or negative life events on adult depression.95-98 These genes are interesting candidates because they regulate the stress response via the hypothalamic-pituitary-adrenal (HPA) axis.99 Additional replications of these candidates would be helpful to further evaluate their role in shaping risk for depression. Evidence for other candidates, such as BDNF, has been more mixed. For instance, a recent review found stronger evidence to support interactions with the BDNF Val66Met polymorphism and stressful life events compared to childhood adversity.100 As we later discuss, genome-wide approaches to GxE remain an important, but relatively unexplored area.
