Out of 10,192 COPDGene study subjects, 9,970 passed initial GWAS QC. Additional QC for CNV estimation excluded 894 subjects, leaving 9,076 subjects (2,889 AAs; 6,187 NHWs) for analysis of polymorphic CNVs. Table 1 presents the demographic characteristics and distribution of the smoking phenotypes among males and females for these 2,889 AA and 6,187 NHW subjects. None of our genome-wide CNV association results was significant in the larger group of 6,187 NHW COPDGene subjects, so we here limit our subsequent discussion to AA subjects only.
