1,160 SNPs with an association P value less than 1 × 10−4 in the INDEPENDENT PGC sample, 82% showed enrichment in the CLOZUK cases (P = 3.44 × 10−113), confirming that very large numbers of true associations will be discovered among these SNPs with increased sample sizes. Additionally, the new sample introduced in this study (CLOZUK2) was compared by the same methods with the PGC dataset and showed results consistent with the full CLOZUK analysis, providing molecular validation of this sample as a schizophrenia sample (Supplementary Table 1).
