Using the same model, analysis of MD within clusters of significant FA discrepancy yielded no differences between groups (see Figure 2). However, a whole-brain analysis of MD revealed small but significant differences in two areas. Inferior to the right occipital-cuneus and adjacent the lingual gyrus, MJ+ALC users had higher MD than controls (P<0.01). Contrary to hypotheses, users showed lower MD than controls in the left inferior longitudinal fasciculus (P<0.01).