After applying filtering and meta-analysis, results were available for 16,511,702, 15,625,945, and 15,724,050 markers for Consumption, Problems, and Maxdrinks, respectively. For each phenotype, results for 33–35% of the markers were only testable (MAC > 40) in the AFR ancestry group due to frequency. The meta-analyses showed no evidence of genomic inflation with λ1,000s of 1.0001 (Problems), 0.9997 (Consumption), and 0.9994 (Maxdrinks). Across the three phenotypes, FDR analysis showed 187 markers with q < 0.50. All markers with FDR q < 0.5 are listed in Supplementary Table 1, with summary statistics and information on nearby genes. These 187 markers map to 53 genomic bins (Supplementary Table 1). Seven bins contained at least one genome-wide significant (GWS; p < 5 × 10−8) marker. However, in all but one of these bins the signal was limited to the AFR group. Using stricter genome-wide significance for samples of African ancestry (p < 1 × 10−8), only one AFR specific bin remained GWS.
