We report 2 meta-analyses. The first includes a total of 14 250 participants from studies published through March 2009 that included data on stressful life events, 5-HTTLPR genotype, and depression in a consistent manner. The second meta-analysis includes sex-specific data on a total of 10 943 participants based on the individual-level data from the subset of the studies from which it was available. Several studies were not included in these meta-analyses due to lack of sufficient data for analysis or differential operationalization of the key study variables, most commonly, the use of a continuous outcome measure for depression, which did not allow for logistic regression as was performed for the included studies.
