(SP), and suicide attempt (SA). Subsequently, we conducted a discovery GEWIS to verify whether SDs interact with the individual genetic variability in the context of SI. Finally, based on the high genetic overlap between suicidality and depression observed across multiple large-scale GWAS4,7,8, we verified whether depression genetic risk interacts with polysubstance dependence in the context of suicidality spectrum. Supplemental Fig. 1 provides a graphical overview of the analyses conducted.
