We used data from the Resource for Genetic Epidemiology Research on Adult Health and Aging study (GERA, phs000674.v1.p1)36,37. This is a study led by the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) and the UCSF Institute for Human Genetics with over 100,000 participants. We downloaded the data from dbGaP and performed GWAS followed by S-PrediXcan analysis of 22 conditions available in the European subset of the cohort.