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Chunk #25 — DISCUSSION

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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.
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permit progenitors to dwell and expand within the presumptive white matter before colonizing the cortical mantle, and may instead be biased towards rapid entry into the cortical gray matter. These observations in human SCZ glial chimeric mice are especially intriguing given the well-described hypomyelination of schizophrenic patients (Davis et al., 2003; Najjar and Pearlman, 2015; Sigmundsson et al., 2001; Voineskos et al., 2013), particularly so in early onset disease (Gogtay et al., 2008; Gogtay and Rapoport, 2008; Samartzis et al., 2014).