For most individuals affected by schizophrenia, the first onset of symptoms is preceded by a prodromal period characterized by attenuated psychotic symptoms, anxiety, social and role dysfunction, and affective symptoms (Häfner et al., 2003). Early recognition of individuals who later develop psychosis holds the promise of preventing or delaying onset through early intervention (e.g., Corcoran et al., 2010). However, despite considerable efforts in studying individuals at clinical high risk (CHR) for psychosis (see Fusar-Poli et al., 2013, for a recent review), little is known about the underlying pathophysiology of emerging psychosis.
