LD Score regression (LDSC)35 was used to estimate the hSNP2 of BD from GWAS summary statistics. hSNP2 was converted to the liability scale, using a lifetime BD prevalence of 2% and 1%. LDSC bivariate genetic correlations attributable to genome-wide SNPs (rg) were estimated with 255 human diseases and traits from published GWAS and 514 GWAS of phenotypes in the UK Biobank from LD Hub48. Adjusting for the number of traits tested, the Bonferroni-corrected P-value thresholds were P < 1.96 × 10−4 and P < 9.73 × 10−5, respectively.
