As a preliminary exploration, we examined the relationship of each SNP genotype to the symptom count for each syndrome, using an additive model without adjustment for sex (ANOVA). The results of these analyses are given in the right-hand portion of Table III. As the Table demonstrates, nominally significant p values are observed for AD, ND and CD throughout the area of strong linkage disequilibrium with the notable exception of rs11503016. However, this pattern of significant associations with AD, ND and CD abruptly ends centromeric to exon three. In contrast, to the strong associations consistently noted for the substance use syndromes, only one nominally significant association between genotype and either MDD or ASPD was noted (at rs11503016 for MDD).
