Chunk #50 — Results and Discussion — AM3506 selectively elevated brain anandamide

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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

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For this and subsequent experiments, we used the 129S1/SvImJ (S1) inbred mouse strain that provides a model of impaired fear extinction that can be rescued with pharmacological treatments.23,24