Our analyses identified 16 unique pathways that were shared between schizophrenia and ND (Table 4). The most noticeable pathways were Calcium Signaling, Long-Term Potentiation, Neuroactive Ligand-Receptor Interaction, Phosphatidylinositol Signaling, Cell Adhesion Molecules, and Regulation of Actin Cytoskeleton pathways. Some of these pathways (Calcium Signaling, Long-Term Potentiation, Cell Adhesion Molecules, and Regulation of Actin Cytoskeleton) had been reported to be involved in schizophrenia272829303132, others (Cell Adhesion Molecules and Neuroactive Ligand-Receptor Interaction) had been implicated in ND3334. We found that these pathways were enriched in the genes associated with both ND and schizophrenia. Additionally, pathways involved in cardiomyopathy, GnRH signaling, gastric acid secretion and Alzheimer’s disease were also found to be shared between schizophrenia and ND. In the pathway network interaction analyses, we found a network of crosstalk between pathways (Fig. 1), with the Long-Term Potentiation located at the center of these interactions.
