We analyzed genomic data from 28 OCD case-control cohorts including 53,660 OCD cases and 2,044,417 controls of European ancestry. Supplementary Table 1 provides an overview of the individual cohorts. A subset of the cases and controls have been included in previous studies10,51,85 and preprints12,13, as described in Supplementary Note 2. Among all included individuals, 323 cases were part of a parent-proband trio; in these cases, parents were used as pseudo-controls. A total of 20,427 cases met DSM-593 or ICD-1094 criteria for OCD as assessed by a healthcare professional or derived from (electronic) health records, while the remaining 32,233 cases were based on self-reported OCD diagnosis (23andMe, AGDS, and parts of UKBB). Cohort-specific sample and analytic details can be found in Supplementary Note 2. Data collections were approved by the relevant institutional review boards at all participating sites, and all participants provided written informed consent.
