Hence, the overall aim of the CoFaM Study is to investigate the long-term clinical course of cognitive dimensions in depression and its functional (psychosocial) correlates. In addition, the study aims to identify biological “genomic” correlates of these cognitive dimensions of depression. By taking a prospective approach and by including a healthy control group, the study will increase the understanding of the cognitive dimensions of depression, its biological correlates, and its functional outcomes, etiology, pathophysiology, and state vs. trait characterization.