While rs279845 was associated with age at onset of alcohol dependence symptoms (p = 0.02), the greatest risk was noted for this with two copies of the risk allele (A/A) (Figure 2b). Adjusting for sex reduced the effect of genotype. As shown in Figure 2b and in Table 5, coding the genotype for a dominance model did not fit the data well. In contrast, a recessive model for genotype (A/A versus A/T and T/T) fitted well. Interestingly, the interaction between genotype (recessive model) and sex was significant at p = 0.05 and rs279845 influenced age at onset of alcohol dependence symptoms in women alone (data not shown).
