The MOODS26 C++ library (Version 1.9.3) was used for identifying peaks containing a motif match, using a p-value cutoff of 5×10−5. As background frequencies we used the nucleotide frequencies across all peaks. We wrapped the MOODS library into an R package, motifmatchr, which enables fast determination of motif presence or positions within genomic regions. The package is available at www.github.com/GreenleafLab/motifmatchr and https://bioconductor.org/packages/devel/bioc/html/motifmatchr.html.
