Tgfa, with gene expression increased in the CA group, over-expressing mice display greater ethanol preference than their wild-type counterparts (Hilakivi-Clarke and Goldberg, 1995); and (d) a gene moderately similar to Zfp91 is altered in the prefrontal cortex of alcoholics (Flatscher-Bader et al., 2005), with Zfp91 gene expression increased in the CA group of the present study as well. The results of the GO analysis (Table 2) also suggest that significant changes are occurring in intracellular signaling systems, involving protein kinase activity, G-protein coupled receptor protein signaling, and MAPK activity. These changes in intracellular signaling systems may indicate that major neuronal alterations occurred in the ACB of the CA group.
