by the GxE parameter estimate) evidenced crossovers in which the product of the two slopes was negative. This suggests that these top associations may not necessarily reflect real differential susceptibility in which individuals are responding differently to the environment. Equally important, six SNPs in the pseudo-GWGEI model evidenced lower p values than the top association in the “real” GWGEI model. For instance, rs17005475 and rs7609257 both had pseudo-GWGEI p values of less than 10–6.
