The meta-analysis results (P-values per SNP) were used as the input to compute P-values at the gene level. We performed these analyses in KGG (Li et al. 2012). A P-value of 2.87 × 10−6 was used as the threshold for genome-wide significance in these gene-wide analyses, based on controlling for the false-discovery rate (Benjamini and Hochberg 1995).
