The addiction-rf PRS was associated with general and specific SUD liabilities in an independent sample. The addiction-rf PRS predicted ~6% of OUD variance, which is nearly half the total SNP-heritability of OUD16. The addiction-rf PRS also predicted variance in cocaine use disorder (CoUD); as CoUD was not included in the development of the addiction-rf (due to lack of a well-powered CoUD GWAS), these findings highlight the generalizability of the addiction-rf beyond alcohol, tobacco, cannabis and opioids.
