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Chunk #27 — Results — Recent life stress

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Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology.
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In a prior report on a subsample (n = 200) of the DNS (Nikolova et al. 2012), we found evidence that recent life stress interacted with right VS reactivity to predict positive affect (as assessed via the CES-D). In this larger sample, left VS reactivity in interaction with recent life stress exposure was significantly positively associated with MASQ-SF anhedonic depression scores (ΔR2 = 0.0047, b = −1.5303, F1,816 = 3.86, p = 0.0496) and positive affect as measured by the CES-D at a trend level (ΔR2 = 0.0038, b = −0.2934, F1,816 = 3.18, p = 0.0747). The direction of these interactions is consistent with our prior report, and is independent of ELS exposure (MASQ anhedonic depression: ΔR2 = 0.0047, b = −1.5273, F1,815 = 4.46, p =0.0349; CES-D positive affect: ΔR2 = 0.0038, b = −0.2928, F1,815 = 3.57, p = 0.059). However, the strength of these effects were reduced with the inclusion of sex, age, ethnicity, and diagnosis of any psychiatric disorder excluding depression as covariates in the models (MASQ anhedonic symptoms: p = 0.0633; CES-D positive affect: