were minimized through principal component analysis or similar methods. Detailed information about the data collection and analysis process can be found in the original study41. Human post-mortem brain samples (COGA-INIA) samples were obtained from the New South Wales Tissue Resource Centre at the University of Sydney (http://sydney.edu.au/medicine/pathology/btrc/). Fresh frozen samples of the superior frontal gyrus were collected from each post-mortem sample after obtaining ethical approval for the COGA research project from Icahn School of Medicine and the Scientific Review Committee at New South Wales Tissue Resource Centre at the University of Sydney. The samples were genotyped using the UK Biobank Axiom array as part of the COGA-INIA collaboration.
