variation in BMI, body shape, and body composition may also influence extreme dysregulation of these weight-related features in anorexia nervosa. This pattern of observations complements prior strong evidence for the involvement of neural mechanisms in obesity (34). Finally, positive correlations with “favorable” metabolic phenotypes (i.e., HDL and lipid measures) and negative correlations with “unfavorable” metabolic phenotypes (i.e., fasting insulin, fasting glucose, HOMA-IR) encourage additional exploration of the role metabolic factors may play in extreme dysregulation of appetite and weight in anorexia nervosa.
