Chunk #40 — Materials and Methods — Gene scores

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Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics.

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Under the null hypothesis, it can be shown that the Z-scores of n SNPs in our gene region as multivariate normal: z∼Nn(0,Σ) where Σ is the pair-wise SNP-by-SNP correlation matrix (see Section ‘Derivation of the sum score’ for details).