As stated above, our analyses will fall into two main groups of data: a well-characterized, narrowly defined set of subjects similar to those included in the original study, and a broadly defined group of subjects. Each of these groups will be investigated based on two stressor classes: narrow (childhood maltreatment – including physical and sexual abuse as well as physical neglect occurring before age 17) and broad (any lifetime stressful events (e.g. death of family member, job loss, assault, life threatening illness)). The first group of subjects will consist of adults aged 21 to 30, who did not have depression prior to a 5-year window before assessment, and for whom stress exposure is known to have occurred before any current depression. Other than childhood maltreatment, lifetime stressful events will only be considered if they occurred no more than 5 years prior to assessment. The second, broader group of subjects will have no age restriction. Examination of the broader group of subjects will include additional analyses which drop requirements related to the timing of the stressors.
