Chunk #11 — MATERIALS AND METHODS — Subjects and Phenotype Measurement

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Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).

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was conducted (for details see Kuo et al., 2006). A factor score of withdrawal severity for each individual was derived based on the item loadings on one major factor, which accounted for 70% of the variance in these symptoms based on the entire IASPSAD sample.